Using F# for HTML5 Web Applications
Option 1: Use WebSharper
WebSharper supports F# and can be used to make F# client-side or cross-tier HTML5 web apps. These can be used from any HTML5-enabled browser.
Option 2: Use Fable
Fable is an F# to JS compiler designed to generate clean and standard code in order to maximize interoperability in both ways. It integrates with most of JS development pipelines like Babel, Webpack or React Hot Loader. Fable allows you develop not only web apps but also node.js, desktop with Electron or mobile with React native.