Option 1: Use WebSharper

WebSharper WebSharper supports F# and can be used to make F# client-side or cross-tier HTML5 web apps. These can be used from any HTML5-enabled browser.

Option 2: Use FunScript

FunScript is a standalone converter from F# to JavaScript. It also offers strongly typed interoperability with any components given a TypeScript signature.

Option 3: Use F# on the Server with JavaScript, CoffeeScript or TypeScript on the client

You can use F# on the server with JavaScript, CoffeeScript or TypeScript as the front end, in conjunction with modern JS/HTML5 web frameworks. More details at F# Web Programming.